生物
小RNA
癌症
非翻译区
功能(生物学)
癌症研究
三素数非翻译区
基因
上皮-间质转换
信使核糖核酸
基因表达调控
计算生物学
细胞生物学
遗传学
转移
作者
Zhichao Wang,Wenjie Xie,Hongzai Guan
标识
DOI:10.1089/dna.2022.0557
摘要
miRNAs are a type of small endogenous noncoding RNA composed of 20-22 nucleotides that can regulate gene expression by targeting the 3' untranslated region of mRNA. Many investigations have discovered that miRNAs have a role in the development and progression of human cancer. Several aspects of tumor development are affected by miR-425, including growth, apoptosis, invasion, migration, epithelial-mesenchymal transition, and drug resistance. In this article, we discuss the properties and research development of miR-425, focusing on the regulation and function of miR-425 in various cancers. Furthermore, we discuss the clinical implications of miR-425. This review may broaden our horizon for better understanding the role of miR-425 as biomarkers and therapeutic targets in human cancer.
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