溃疡性结肠炎
结肠炎
炎症
多糖
脂多糖
粘蛋白
肠道菌群
拟杆菌
脂多糖结合蛋白
封堵器
微生物学
髓过氧化物酶
化学
药理学
脆弱类杆菌
免疫学
生物
医学
细菌
生物化学
紧密连接
疾病
抗生素
内科学
遗传学
急性期蛋白
作者
Hanyu Lu,Mingyue Shen,Yi Chen,Qiang Yu,Ting Chen,Jianhua Xie
标识
DOI:10.1016/j.foodres.2023.112630
摘要
Ulcerative colitis (UC) treatment usually involves either drug therapy or surgery. Natural food polysaccharides have showed great potential for preventing UC. In this study, the therapeutic effects of Cyclocarya paliurus (Batal.) Iljinskaja polysaccharide (CP) and Chinese yam polysaccharide (CYP) on dextran sodium sulfate (DSS)-induced mice UC model and their underlying mechanisms were explored. The results suggested that CP and CYP could improve colitis symptoms in DSS-induced mice, enhance the production of IL-10, inhibit cytokines (IL-1β, TNF-α) and reduce MPO activity. Furthermore, they maintained the integrity of intestine by improving the expression of mucin MUC-2, ZO-1 and occludin, which in turn reduced the contents of lipopolysaccharide binding protein (LBP) and endotoxin (ET) in serum and oxidative stress in liver. Finally, they modulated the composition and metabolism of gut microbiota. Notably, Alistipes and Bacteroides were the specific genera in CP and CYP groups, respectively. These findings indicated that polysaccharides might alleviate the development of colitis and inform other relevant studies.
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