医学
家族性高胆固醇血症
危险系数
队列
胆固醇
比例危险模型
内科学
弗雷明翰风险评分
弗雷明翰心脏研究
队列研究
后代
心脏病学
疾病
置信区间
遗传学
怀孕
生物
作者
Yiyi Zhang,Jacqueline S. Dron,Brandon K. Bellows,Amit V. Khera,Junxiu Liu,Pallavi Balte,Elizabeth C. Oelsner,Sami S. Amr,Matthew S. Lebo,Anna Nagy,Gina M. Peloso,Pradeep Natarajan,Jerome I. Rotter,Cristen J. Willer,Eric Boerwinkle,Christie M. Ballantyne,Pamela L. Lutsey,Myriam Fornage,Donald M. Lloyd‐Jones,Lifang Hou
出处
期刊：JAMA Cardiology
[American Medical Association]
日期：2024-01-31
卷期号：9 (3): 263-263
被引量：6
标识
DOI：10.1001/jamacardio.2023.5366
摘要
Familial hypercholesterolemia (FH) is a genetic disorder that often results in severely high low-density lipoprotein cholesterol (LDL-C) and high risk of premature coronary heart disease (CHD). However, the impact of FH variants on CHD risk among individuals with moderately elevated LDL-C is not well quantified.
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