细胞外基质
骨愈合
细胞生物学
再生(生物学)
骨质疏松症
人口
医学
成纤维细胞
伤口愈合
化学
生物
免疫学
内科学
解剖
生物化学
环境卫生
体外
作者
Hui Wang,Qi Li,Clement Shema,Kanli Jiang,Peng Ren,Wen He,Lei Wang
标识
DOI:10.3389/fendo.2024.1350958
摘要
With the development of social population ageing, bone fracture has become a global public health problem due to its high morbidity, disability and mortality. Fracture healing is a complex phenomenon involving the coordinated participation of immigration, differentiation and proliferation of inflammatory cells, angioblasts, fibroblasts, chondroblasts and osteoblasts which synthesize and release bioactive substances of extracellular matrix components, Mortality caused by age-related bone fractures or osteoporosis is steadily increasing worldwide as the population ages. Fibroblasts play an important role in the process of fracture healing. However, it is not clear how the growth factors and extracellular matrix stiffness of the bone-regeneration microenvironment affects the function of osteoblasts and fibroblasts in healing process. Therefore, this article focuses on the role of fibroblasts in the process of fracture healing and mechanisms of research progress.
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