An Overview on Cyclodextrin and Its Derivatives Encapsulated Inclusion Complex: Preparation Methods and Influencing Factors

Inclusion Complex formation is supported by non-covalent interaction between host and guest molecules. Cyclodextrins are supramolecular hosts with distinct structural characteristics that can enclose a diverse spectrum of viable compounds. The toroidal shape of CD offers the hydrophobic environment in the cavity where the guest moieties are entrapped which undergoes the physicochemical transformation and results into a superior physical, chemical and biological profiles. This review describes the chemical behavior of pharmaceuticals, both natural and synthetic, as well as other related compounds complexed with cyclodextrins. The study focuses on the commonly employed preparation methods of inclusion complexes and influencing factors to demonstrate host-guest interaction. The study demonstrates the possible stoichiometric combinations of cyclodextrins with the active pharmaceutical and organic molecules. The review also provides instances of synthetic pharmaceuticals that have combined with cyclodextrin to create inclusion products, demonstrating how cyclodextrins can be exploited to create biological substances with novel features and advance therapeutic research.