已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

The human subthalamic nucleus transiently inhibits active attentional processes

丘脑底核 局部场电位 神经科学 基底神经节 心理学 运动前神经元活动 脑深部刺激 医学 帕金森病 中枢神经系统 病理 疾病
作者
Cheol Soh,Mario Hervault,Nathan H. Chalkley,Cathleen M. Moore,Andrea Rohl,Qiang Zhang,Ergun Y. Uç,Jeremy D.W. Greenlee,Darcy A. Diesburg
出处
期刊:Brain [Oxford University Press]
被引量:1
标识
DOI:10.1093/brain/awae068
摘要

Abstract The subthalamic nucleus (STN) of the basal ganglia is key to the inhibitory control of movement. Consequently, it is a primary target for the neurosurgical treatment of movement disorders like Parkinson’s Disease, where modulating the STN via deep-brain stimulation (DBS) can release excess inhibition of thalamo-cortical motor circuits. However, the STN is also anatomically connected to other thalamo-cortical circuits, including those underlying cognitive processes like attention. Notably, STN-DBS can also affect these processes. This suggests that the STN may also contribute to the inhibition of non-motor activity, and that STN-DBS may cause changes to this inhibition. We here tested this hypothesis in humans. We used a novel, wireless outpatient method to record intracranial local field potentials (LFP) from STN DBS implants during a visual attention task (Experiment 1, N=12). These outpatient measurements allowed the simultaneous recording of high-density EEG, which we used to derive the steady-state visual evoked potential (SSVEP), a well-established neural index of visual attentional engagement. By relating STN activity to this neural marker of attention (instead of overt behavior), we avoided possible confounds resulting from STN’s motor role. We aimed to test whether the STN contributes to the momentary inhibition of the SSVEP caused by unexpected, distracting sounds. Furthermore, we causally tested this association in a second experiment, where we modulated STN via DBS across two sessions of the task, spaced at least one week apart (N=21, no sample overlap with Experiment 1). The LFP recordings in Experiment 1 showed that reductions of the SSVEP after distracting sounds were preceded by sound-related γ-frequency (>60Hz) activity in the STN. Trial-to-trial modeling further showed that this STN activity statistically mediated the sounds’ suppressive effect on the SSVEP. In Experiment 2, modulating STN activity via DBS significantly reduced these sound-related SSVEP reductions. This provides causal evidence for the role of the STN in the surprise-related inhibition of attention. These findings suggest that the human STN contributes to the inhibition of attention, a non-motor process. This supports a domain-general view of the inhibitory role of the STN. Furthermore, these findings also suggest a potential mechanism underlying some of the known cognitive side-effects of STN-DBS treatment, especially on attentional processes. Finally, our newly-established outpatient LFP recording technique facilitates the testing of the role of subcortical nuclei in complex cognitive tasks, alongside recordings from the rest of the brain, and in much shorter time than perisurgical recordings.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
xll完成签到,获得积分10
2秒前
沉默清炎发布了新的文献求助30
3秒前
江知之完成签到 ,获得积分0
3秒前
俊逸鹏笑完成签到,获得积分10
4秒前
不爱吃香菜完成签到 ,获得积分10
8秒前
西瓜完成签到 ,获得积分10
9秒前
15秒前
桐桐应助yuna采纳,获得80
16秒前
Talha完成签到,获得积分10
21秒前
23秒前
咕噜咕噜发布了新的文献求助10
28秒前
30秒前
33秒前
JamesPei应助上官雨时采纳,获得10
34秒前
35秒前
38秒前
思源应助zz采纳,获得10
41秒前
41秒前
英俊的铭应助Hosea采纳,获得10
42秒前
严泰完成签到,获得积分10
43秒前
猪猪侠发布了新的文献求助10
43秒前
复杂念梦完成签到 ,获得积分10
43秒前
45秒前
yuna发布了新的文献求助80
45秒前
47秒前
junya完成签到,获得积分10
47秒前
winston完成签到,获得积分10
48秒前
49秒前
49秒前
嘻嘻汐泽发布了新的文献求助10
52秒前
明昼完成签到,获得积分10
53秒前
祺yix完成签到,获得积分10
54秒前
上官雨时发布了新的文献求助10
55秒前
团团完成签到 ,获得积分10
55秒前
winston发布了新的文献求助10
57秒前
58秒前
yuna完成签到,获得积分10
58秒前
未来可期完成签到,获得积分10
59秒前
ZYY123发布了新的文献求助10
1分钟前
高分求助中
Evolution 10000
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
юрские динозавры восточного забайкалья 800
English Wealden Fossils 700
Foreign Policy of the French Second Empire: A Bibliography 500
Chen Hansheng: China’s Last Romantic Revolutionary 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3146435
求助须知:如何正确求助?哪些是违规求助? 2797816
关于积分的说明 7825904
捐赠科研通 2454242
什么是DOI,文献DOI怎么找? 1306225
科研通“疑难数据库(出版商)”最低求助积分说明 627679
版权声明 601503