Formulation, Design, Optimization, and Characterization of Novel Long-acting Injectable Dosage Form of Anti-Psychotic Drug

药品 剂型 药理学 微球 药物输送 化学 材料科学 色谱法 生物医学工程 纳米技术 医学 化学工程 工程类
作者
Niraj Patel,Rakesh Patel,Abhay Dharamsi
出处
期刊:Current Drug Therapy [Bentham Science]
卷期号:19 (6): 727-741
标识
DOI:10.2174/0115748855270864240104094025
摘要

Background: The current research aimed to create and analyze a new long-acting Brexpiprazole (BRX) injectable for successful anti-psychotic drug therapy in order to decrease dosage frequency and increase patient compliance. Systems for drug transport to particular body sites or regulating release rates with accuracy are known as drug delivery systems (DDS). By affixing the drug to a carrier particle like liposomes, nanoparticles, microspheres, etc., which modifies the drug's absorption and release properties, using carrier technology, drugs may be delivered in an intelligent manner. Methods: Utilizing Resomer RG 502 H and RESOMER® RG 752 H extended-release Polymer, Using a quasi-emulsion solvent diffusion, microspheres were made, and emulsification and solvent evaporation process. Results: The produced microspheres were assessed for stability tests, in vitro drug release, flow characteristics, and drug entrapment efficiency. FTIR experiments were used to establish how well the drug excipients worked together. The acarbose microspheres that were created had an 89.9 to 96.1 percent drug entrapment efficiency. The impact of factors like polymer content on medication release was studied. The Stability study of the formulation was carried out under different conditions, and data were established. Comparative pharmacokinetic studies between marketed oral formulation and Brexpirazole microsphere test formulations in Wistar/SD Rats were carried out and concluded. Conclusion: Brexpiprazole (BRX) novel long-acting injectable formulation, could be used effectively for the treatment of mentally challenged anti-psychotic patients worldwide.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
风中梦蕊完成签到 ,获得积分10
1秒前
852应助YC采纳,获得10
2秒前
llbeyond应助科研通管家采纳,获得30
5秒前
和平使命应助科研通管家采纳,获得10
5秒前
慕青应助科研通管家采纳,获得10
5秒前
杰行天下完成签到,获得积分10
8秒前
王小西完成签到,获得积分10
8秒前
organic tirrttf完成签到,获得积分10
9秒前
chengwanying完成签到 ,获得积分10
10秒前
tingalan完成签到,获得积分10
10秒前
Kelly1426完成签到,获得积分10
10秒前
10秒前
mingcheng完成签到,获得积分10
12秒前
刚子完成签到 ,获得积分0
14秒前
优雅沛文完成签到 ,获得积分10
14秒前
谦虚发布了新的文献求助10
16秒前
自信放光芒~完成签到 ,获得积分10
20秒前
msl2023完成签到,获得积分10
21秒前
迁小yan完成签到 ,获得积分10
22秒前
顺利毕业完成签到 ,获得积分10
28秒前
YAN完成签到,获得积分10
29秒前
摸鱼人完成签到,获得积分10
33秒前
书生完成签到,获得积分10
35秒前
Zzy完成签到 ,获得积分10
36秒前
乔杰完成签到 ,获得积分10
36秒前
drizzling完成签到,获得积分10
36秒前
朴实寻琴完成签到 ,获得积分10
39秒前
GJL关注了科研通微信公众号
41秒前
meng完成签到,获得积分10
42秒前
du2002完成签到,获得积分10
43秒前
鱼丸完成签到 ,获得积分10
44秒前
44秒前
Shabby0-0完成签到,获得积分10
45秒前
CAST1347完成签到,获得积分10
50秒前
天令发布了新的文献求助30
50秒前
泥娃娃完成签到 ,获得积分10
50秒前
楚奇完成签到,获得积分10
50秒前
任性青烟完成签到,获得积分10
52秒前
嘟嘟豆806完成签到 ,获得积分10
54秒前
55秒前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052675
求助须知:如何正确求助?哪些是违规求助? 2709898
关于积分的说明 7418335
捐赠科研通 2354494
什么是DOI,文献DOI怎么找? 1246139
科研通“疑难数据库(出版商)”最低求助积分说明 605951
版权声明 595921