化学
区域选择性
钯
催化作用
功能群
组合化学
有机化学
聚合物
作者
Xinglong Zhang,Meng‐Yue Wang,Hui-Jin Liu,Yong‐Qiang Wang
标识
DOI:10.1021/acs.orglett.3c03568
摘要
The development of an efficient method for the synthesis of C4 oxy-substituted indoles is an appealing yet challenging task. Herein, we report a general palladium-catalyzed TDG approach for the direct C4-H acyloxylation of indoles. The protocol features atom and step economy, excellent regioselectivity, and good tolerance of functional groups. Moreover, the reaction can accommodate a range of carboxylic acids including benzoic acids, phenylacetic acids, and aliphatic acids.
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