黄芩苷
肾毒性
药理学
急性肾损伤
氧化应激
医学
肾
肾功能
化学
内科学
高效液相色谱法
色谱法
作者
Wenhua Chen,Ke Zhang,Huanyue Cui,Jiacun Li,Dahong Yao,Shuyun Wang,Xing Tian,Wei-Bing Kou,Jian Huang,Hangyu Wang,Jinhui Wang
标识
DOI:10.1016/j.biopha.2024.116276
摘要
Drug nephrotoxicity has high fatality rates and complications. To study this conditional, traditionally, Gentamicin (GM) is used to induce acute injury and establish a nephrotic syndrome model. Baicalin, a flavonoid derived from baicalin with potent anti-inflammatory and antioxidant activity, has been used to treat various inflammatory diseases. This study aims to investigate the process of baicalin-2-ethoxyethyl ester (BAE) synthesis and its therapeutic effect on GM-induced acute kidney injury (AKI). Briefly, baicalin was processed by various reactions to yield BAE. A GM-induced AKI model was established for in vivo evaluation of the protective effect and mechanism of BAE. The results indicated that BAE reduced serum creatinine and urea nitrogen levels and improved pathological alterations, inflammatory responses, and oxidative stress in renal tissues. Furthermore, it was revealed that BAE might exert anti-inflammatory and anti-oxidative responses during AKI via the NF-κB signaling pathway regulation. The findings imply that BAE has a protective impact on the kidneys and might serve as a potent medicine for treating renal damage.
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