静脉注射
血管生成
转移
肿瘤进展
肿瘤微环境
癌症研究
外渗
间充质干细胞
生物
癌症
癌细胞
转化生长因子
转分化
细胞生物学
免疫学
肿瘤细胞
干细胞
遗传学
作者
Tetsuro Watabe,Kazuki Takahashi,Kristian Pietras,Yasuhiro Yoshimatsu
标识
DOI:10.1016/j.semcancer.2023.04.007
摘要
Tumor cells evolve in tumor microenvironment composed of multiple cell types. Among these, endothelial cells (ECs) are the major players in tumor angiogenesis, which is a driver of tumor progression and metastasis. Increasing evidence suggests that ECs also contribute to tumor progression and metastasis as they modify their phenotypes to differentiate into mesenchymal cells through a process known as endothelial-mesenchymal transition (EndoMT). This plasticity of ECs is mediated by various cytokines, including transforming growth factor-β (TGF-β), and modulated by other stimuli depending on the cellular contexts. Recent lines of evidence have shown that EndoMT is involved in various steps of tumor progression, including tumor angiogenesis, intravasation and extravasation of cancer cells, formation of cancer-associated fibroblasts, and cancer therapy resistance. In this review, we summarize current updates on EndoMT, highlight the roles of EndoMT in tumor progression and metastasis, and underline targeting EndoMT as a potential therapeutic strategy.
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