Unstructured polypeptides as a versatile drug delivery technology

聚乙二醇化 免疫原性 药物输送 生物制药 纳米载体 聚乙二醇 PEG比率 纳米技术 计算机科学 材料科学 化学 生物化学 生物 生物技术 免疫系统 财务 经济 免疫学
作者
Yue Ji,Dingkang Liu,Haichao Zhu,Lichen Bao,Ruilong Chang,Xiangdong Gao,Jun Yin
出处
期刊:Acta Biomaterialia [Elsevier]
卷期号:164: 74-93
标识
DOI:10.1016/j.actbio.2023.04.019
摘要

Although polyethylene glycol (PEG), or “PEGylation” has become a widely applied approach for improving the efficiency of drug delivery, the immunogenicity and non-biodegradability of this synthetic polymer have prompted an evident need for alternatives. To overcome these caveats and to mimic PEG -or other natural or synthetic polymers- for the purpose of drug half-life extension, unstructured polypeptides are designed. Due to their tunable length, biodegradability, low immunogenicity and easy production, unstructured polypeptides have the potential to replace PEG as the preferred technology for therapeutic protein/peptide delivery. This review provides an overview of the evolution of unstructured polypeptides, starting from natural polypeptides to engineered polypeptides and discusses their characteristics. Then, it is described that unstructured polypeptides have been successfully applied to numerous drugs, including peptides, proteins, antibody fragments, and nanocarriers, for half-life extension. Innovative applications of unstructured peptides as releasable masks, multimolecular adaptors and intracellular delivery carriers are also discussed. Finally, challenges and future perspectives of this promising field are briefly presented. Polypeptide fusion technology simulating PEGylation has become an important topic for the development of long-circulating peptide or protein drugs without reduced activity, complex processes, and kidney injury caused by PEG modification. Here we provide a detailed and in-depth review of the recent advances in unstructured polypeptides. In addition to the application of enhanced pharmacokinetic performance, emphasis is placed on polypeptides as scaffolders for the delivery of multiple drugs, and on the preparation of reasonably designed polypeptides to manipulate the performance of proteins and peptides. This review will provide insight into future application of polypeptides in peptide or protein drug development and the design of novel functional polypeptides.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
自有龙骧完成签到 ,获得积分10
2秒前
dhjic发布了新的文献求助10
2秒前
3秒前
闪闪的从彤完成签到 ,获得积分10
4秒前
gnr2000完成签到,获得积分0
4秒前
posh完成签到 ,获得积分10
6秒前
夏之完成签到,获得积分10
7秒前
jack潘发布了新的文献求助10
7秒前
感动归尘完成签到,获得积分10
7秒前
richhu完成签到,获得积分10
9秒前
joan完成签到 ,获得积分10
9秒前
栗栗完成签到,获得积分10
9秒前
火星上的小蚂蚁完成签到,获得积分0
9秒前
8y24dp发布了新的文献求助10
9秒前
12完成签到,获得积分10
9秒前
彩色毛巾完成签到 ,获得积分10
11秒前
11秒前
壮观以松完成签到,获得积分10
11秒前
甜甜友容完成签到,获得积分10
12秒前
kakaC完成签到,获得积分10
12秒前
jack潘完成签到,获得积分10
13秒前
落后访风完成签到,获得积分10
14秒前
言多必失完成签到,获得积分10
14秒前
14秒前
用行舍藏完成签到,获得积分10
15秒前
老猪佩奇完成签到,获得积分10
16秒前
楚小儿完成签到 ,获得积分10
19秒前
打工是不可能打工的完成签到 ,获得积分10
20秒前
大豆终结者完成签到,获得积分10
21秒前
21秒前
六步郎完成签到,获得积分10
22秒前
Cuz完成签到,获得积分10
22秒前
pigeonKimi完成签到,获得积分0
23秒前
Ada大侦探发布了新的文献求助10
24秒前
米夏完成签到 ,获得积分10
24秒前
acaizr完成签到,获得积分10
24秒前
无解完成签到,获得积分10
25秒前
他的狗完成签到,获得积分10
25秒前
谷粱诗云完成签到,获得积分20
26秒前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052675
求助须知:如何正确求助?哪些是违规求助? 2709926
关于积分的说明 7418483
捐赠科研通 2354527
什么是DOI,文献DOI怎么找? 1246159
科研通“疑难数据库(出版商)”最低求助积分说明 605951
版权声明 595921