前药
多西紫杉醇
化学
合理设计
毒性
药品
药代动力学
药物输送
二硫键
药理学
组合化学
纳米技术
材料科学
化疗
生物化学
有机化学
医学
内科学
作者
Danping Wang,Lingxiao Li,Hezhen Xu,Yixin Sun,Wenxiao Li,Tian Liu,Yan Li,Xianbao Shi,Zhonggui He,Yinglei Zhai,Bingjun Sun,Jin Sun
出处
期刊:Nano Letters
[American Chemical Society]
日期:2023-04-13
卷期号:23 (8): 3549-3557
被引量:13
标识
DOI:10.1021/acs.nanolett.3c00704
摘要
Prodrug-based nanoassemblies have been developed to solve the bottlenecks of chemotherapeutic drugs. The fabricated prodrugs usually consist of active drug modules, response modules, and modification modules. Among three modules, the response modules play a vital role in controlling the intelligent drug release at tumor sites. Herein, various locations of disulfide bond linkages were selected as response modules to construct three Docetaxel (DTX) prodrugs. Interestingly, the small structural difference caused by the length of response modules endowed corresponding prodrug nanoassemblies with unique characteristic. α-DTX-OD nanoparticles (NPs) possessed the advantages of high redox-responsiveness due to their shortest linkages. However, they were too sensitive to retain the intact structure in the blood circulation, leading to severe systematic toxicity. β-DTX-OD NPs significantly improved the pharmacokinetics of DTX but may induce damage to the liver. In comparison, γ-DTX-OD NPs with the longest linkages greatly ameliorated the delivery efficiency of DTX as well as improved DTX's tolerance dose.
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