Exercise effect on the gut microbiota in young adolescents with subthreshold depression: A randomized psychoeducation-controlled Trial

心理教育 随机对照试验 有氧运动 医学 肠道菌群 萧条(经济学) 干预(咨询) 物理疗法 内科学 精神科 免疫学 宏观经济学 经济
作者
Runhua Wang,Yuanyuan Cai,Weicong Lu,Ruoxi Zhang,Robin Shao,Suk-Yu Yau,Brendon Stubbs,Roger S. McIntyre,Kuan‐Pin Su,Guiyun Xu,Liangwen Qi,Kwok–Fai So,Kangguang Lin
出处
期刊:Psychiatry Research-neuroimaging [Elsevier]
卷期号:319: 115005-115005 被引量:19
标识
DOI:10.1016/j.psychres.2022.115005
摘要

This 3-month randomized psychoeducation-controlled trial (RCT) of exercise was undertaken in young adolescents with subthreshold depression to examine the impact on gut microbiota. Participants (aged 12–14 years) were randomly assigned to an exercise or a psychoeducation-controlled group. The exercise intervention arm took moderate-intensity exercise, comprised of 30 min of running per day, 4 days a week for 3 months. Psychoeducation intervention consisted of 6 sessions of group activity including gaming, reading, and singing. The gut microbiota was assessed by metagenomic sequencing. After 3-month moderate-intensity exercise, the intervention group increased the relative abundance of Coprococcus, Blautia, Dorea, Tyzzerella at the genus level, as well as Tyzzerella nexilis, Ruminococcus obeum at species level when compared to the psychoeducation-controlled group. Moreover, EggNOG analyses showed that the defense and signal transduction mechanism were highly enriched after the active intervention, and changes were correlated with improvements in depressive symptoms measured by Chinese Patient Depression Questionnaire 9. The KEGG pathway of neurodegenerative diseases was depleted in the microbiome in young adolescents with subthreshold depression after exercise intervention. This 3-month RCT suggests that at both the genus and species levels, aerobic group exercise intervention improved in depressive symptoms and revealed changes in gut microbiota suggesting beneficial effects.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
冷冷完成签到 ,获得积分10
1秒前
Manyiu发布了新的文献求助10
1秒前
1秒前
千寒完成签到,获得积分10
2秒前
2秒前
2秒前
2秒前
3秒前
3秒前
4秒前
打卡下班应助知性的浩天采纳,获得10
5秒前
幼荷完成签到 ,获得积分10
5秒前
6秒前
aaaaa完成签到,获得积分20
6秒前
6秒前
7秒前
Turing发布了新的文献求助10
7秒前
简洁应助个性的半凡采纳,获得20
7秒前
askaga发布了新的文献求助10
8秒前
8秒前
定西发布了新的文献求助20
8秒前
whisper发布了新的文献求助10
9秒前
绿色发布了新的文献求助20
9秒前
9秒前
科学家完成签到,获得积分10
9秒前
NexusExplorer应助朝韵采纳,获得10
10秒前
10秒前
完美世界应助崔崔采纳,获得10
11秒前
然后先生完成签到,获得积分10
11秒前
hay应助毅诚菌采纳,获得30
11秒前
张YI发布了新的文献求助10
11秒前
11秒前
aaaaa发布了新的文献求助10
11秒前
在水一方应助激昂的白凡采纳,获得10
12秒前
我是老大应助mcf6662采纳,获得10
12秒前
hhh完成签到,获得积分10
12秒前
NexusExplorer应助聪慧的致远采纳,获得10
13秒前
桐桐应助自信的九娘采纳,获得30
13秒前
一粟完成签到,获得积分10
13秒前
柔弱小猫咪完成签到,获得积分10
13秒前
高分求助中
One Man Talking: Selected Essays of Shao Xunmei, 1929–1939 1000
A Chronicle of Small Beer: The Memoirs of Nan Green 1000
From Rural China to the Ivy League: Reminiscences of Transformations in Modern Chinese History 900
Migration and Wellbeing: Towards a More Inclusive World 900
Eric Dunning and the Sociology of Sport 850
Operative Techniques in Pediatric Orthopaedic Surgery 510
The Making of Détente: Eastern Europe and Western Europe in the Cold War, 1965-75 500
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 免疫学 细胞生物学 电极
热门帖子
关注 科研通微信公众号,转发送积分 2912454
求助须知:如何正确求助?哪些是违规求助? 2547620
关于积分的说明 6895505
捐赠科研通 2212361
什么是DOI,文献DOI怎么找? 1175622
版权声明 588174
科研通“疑难数据库(出版商)”最低求助积分说明 575791