胰腺癌
癌症研究
癌症
小分子
计算生物学
生物
医学
生物化学
遗传学
作者
Samantha B. Kemp,Noah Cheng,Nune Markosyan,Rina Sor,Il‐Kyu Kim,Jill Hallin,Jason Shoush,Liz Quinones,Natalie V. Brown,Jared B. Bassett,Nikhil Joshi,Salina Yuan,Molly Smith,William P. Vostrejs,Kia Z. Perez-Vale,Benjamin Kahn,Feiyan Mo,Timothy R. Donahue,Caius G. Radu,Cynthia Clendenin
出处
期刊：Cancer Discovery
[American Association for Cancer Research]
日期：2022-12-06
卷期号：13 (2): 298-311
被引量：332
标识
DOI：10.1158/2159-8290.cd-22-1066
摘要
Pharmacologic inhibition of KRASG12D in pancreatic cancer models with an intact immune system stimulates specific, potent, and durable tumor regressions. In the absence of overt toxicity, these results suggest that this and similar inhibitors should be tested as potential, high-impact novel therapies for patients with PDAC. See related commentary by Redding and Grabocka, p. 260. This article is highlighted in the In This Issue feature, p. 247.
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