类核
线粒体DNA
线粒体分裂
细胞生物学
线粒体融合
线粒体
生物
细胞器
遗传学
基因
大肠杆菌
作者
Hema Saranya Ilamathi,Marc Germain
标识
DOI:10.1016/j.biocel.2023.106492
摘要
Mitochondria are central cellular metabolic hubs. Their function requires proteins encoded by nuclear DNA, but also mitochondrial DNA (mtDNA) whose maintenance is essential for the proper function of the organelle. Defective mtDNA maintenance and distribution are associated with mitochondrial diseases. mtDNA is organized into nucleo-protein complexes called nucleoids that dynamically move along the mitochondrial network and interact with each other. mtDNA replication and nucleoid distribution is an active process regulated by the complex interplay of mitochondrial dynamics, endoplasmic reticulum (ER)-mitochondria contact sites, and cytoskeletal networks. For example, defects in mitochondrial fusion and fission or ER-mitochondria contact sites affect nucleoid maintenance and distribution. In this review, we discuss the process of nucleoid dynamics and the factors regulating nucleoid maintenance and distribution.
科研通智能强力驱动
Strongly Powered by AbleSci AI