Notch信号通路
细胞命运测定
药物开发
生物
信号转导
计算生物学
神经科学
生物信息学
细胞生物学
药品
药理学
遗传学
转录因子
基因
作者
Elliot Medina,Diego Pérez,Daniel Antfolk,Vincent C. Luca
标识
DOI:10.1016/j.tips.2023.09.011
摘要
The Notch pathway regulates a diverse array of cell fate decisions, making it an enticing target in cancer therapy and regenerative medicine. During the early stages of Notch drug development, off-target toxicity precluded the approval of Notch inhibitors for the treatment of cancer. However, recent advances in our understanding of Notch structure and signaling have led to the development of several innovative Notch-based biotechnologies. In addition to new classes of inhibitors, pharmacological Notch activators have been shown to enhance osteogenesis and various aspects of T cell function. Furthermore, the mechanosensitive negative regulatory region (NRR) of the Notch receptor has been converted into synthetic Notch (synNotch) receptors with fully customizable signaling circuits. We review emergent Notch-based compounds, biologics, and cell therapies while highlighting the challenges and opportunities they face on the path to clinical development.
科研通智能强力驱动
Strongly Powered by AbleSci AI