帕金森病
疾病
人口
医学
快速眼动睡眠行为障碍
运动障碍
临床试验
内科学
环境卫生
作者
Ann-Kathrin Schalkamp,Kathryn J. Peall,Neil A. Harrison,Cynthia Sandor
出处
期刊:Nature Medicine
[Springer Nature]
日期:2023-07-03
卷期号:29 (8): 2048-2056
被引量:46
标识
DOI:10.1038/s41591-023-02440-2
摘要
Parkinson’s disease is a progressive neurodegenerative movement disorder with a long latent phase and currently no disease-modifying treatments. Reliable predictive biomarkers that could transform efforts to develop neuroprotective treatments remain to be identified. Using UK Biobank, we investigated the predictive value of accelerometry in identifying prodromal Parkinson’s disease in the general population and compared this digital biomarker with models based on genetics, lifestyle, blood biochemistry or prodromal symptoms data. Machine learning models trained using accelerometry data achieved better test performance in distinguishing both clinically diagnosed Parkinson’s disease (n = 153) (area under precision recall curve (AUPRC) 0.14 ± 0.04) and prodromal Parkinson’s disease (n = 113) up to 7 years pre-diagnosis (AUPRC 0.07 ± 0.03) from the general population (n = 33,009) compared with all other modalities tested (genetics: AUPRC = 0.01 ± 0.00, P = 2.2 × 10−3; lifestyle: AUPRC = 0.03 ± 0.04, P = 2.5 × 10−3; blood biochemistry: AUPRC = 0.01 ± 0.00, P = 4.1 × 10−3; prodromal signs: AUPRC = 0.01 ± 0.00, P = 3.6 × 10−3). Accelerometry is a potentially important, low-cost screening tool for determining people at risk of developing Parkinson’s disease and identifying participants for clinical trials of neuroprotective treatments. UK Biobank moement tracking data show increased performance as compared to symptoms and genetic and lifestyle factors in identifying prodromal Parkinson’s disease in the general population.
科研通智能强力驱动
Strongly Powered by AbleSci AI