Evaluation of the applicability of the lattice radiotherapy technique at the National Cancer Institute - INCA

Lattice is a 3-dimensional spatially fractionated radiotherapy that uses a distribution of high-doses, similar to spheres at vertices of a 3D network or matrix. These vertices that receive the high-dose are called peaks, while the rest of the target volume that receives a lower dose, is called the valley. This study aims to verify the technical feasibility for Spatially Fractionated Radiation Therapy treatment using the Lattice technique performed with VMAT at the National Cancer Institute José Alencar Gomes da Silva - INCA, Unit I. Ten patient cases were selected, with gross tumor volumes ranging from 90 to 1734 cc. A literature review was carried out to determine the geometry, the distribution of peaks and the peak to valley dose ratio that will be used in the Lattice technique plans. The dose distributions in the targets and organs at risk of the Lattice plans were clinically compared with the plans without the peaks. A configuration of spheres with diameter of 1.2 cm, separated center-to-center by 3 cm and with a prescription of 14 Gy in a single dose at these peaks was estabilished, while the valley had a prescription of 25 Gy in 5 fractions. Despite the increase in the prescribed equivalent dose in 2 Gy fractions from 40 Gy to 79.3 Gy, the median increase in doses to the OARs was 2.7%, with a maximum increase of 14.7%. The quality control of the plans was approved through the gamma analysis of the measurements performed with the Varian EPID. These findings demonstrate the technical feasibility of SFRT using the lattice technique with VMAT, and suggest that it may provide an effective delivery of high radiation therapy doses to tumors while minimizing the damage to surrounding healthy tissues.