光热治疗
自愈水凝胶
乳腺癌
转移
癌症研究
癌症治疗
癌症
癌细胞
癌症干细胞
干细胞
乳腺癌转移
材料科学
医学
癌症转移
纳米技术
生物
细胞生物学
内科学
高分子化学
作者
Tianfu Zhang,Ping Wei,Meng Suo,Pan You,Rong Huang,J Chen,Meng Lyu,Qian Zhang,Shipeng Ning,Ben Zhong Tang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-07-24
标识
DOI:10.1021/acsnano.4c04067
摘要
The self-renewal and differentiation properties of cancer stem cells (CSCs) result in chemoresistance in breast cancer. Even though numerous drugs have been developed to target CSCs, they have suffered from inefficient delivery and accumulation at the focal site. Here, a thermoresponsive hydrogel is developed by coencapsulating aggregation-induced emission (AIE)-active photothermal agent and thioridazine (THZ), demonstrating a controllable delivery system triggered by the AIE agent to augment THZ-mediated CSC ablation. Upon near-infrared laser stimuli, the photothermal effect from the AIE agent induces hydrogel deformation for burst drug release. The precise
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