材料科学
干细胞
肺纤维化
生物医学工程
纤维化
纳米技术
细胞生物学
医学
病理
生物
作者
Yujie Zhang,Yuan Zhao,Chenhui An,Yiyang Guo,Yong Ma,Fei Shao,Yonggang Zhang,Kai Sun,Fang Cheng,Changle Ren,Lijun Zhang,Bingbing Sun,Yang Zhang,Huanan Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2024-08-16
卷期号:313: 122757-122757
标识
DOI:10.1016/j.biomaterials.2024.122757
摘要
Recent progress in stem cell therapy has demonstrated the therapeutic potential of intravenous stem cell infusions for treating the life-threatening lung disease of pulmonary fibrosis (PF). However, it is confronted with limitations, such as a lack of control over cellular function and rapid clearance by the host after implantation. In this study, we developed an innovative PF therapy through tracheal administration of microfluidic-templated stem cell-laden microcapsules, which effectively reversed the progression of inflammation and fibrotic injury. Our findings highlight that hydrogel microencapsulation can enhance the persistence of donor mesenchymal stem cells (MSCs) in the host while driving MSCs to substantially augment their therapeutic functions, including immunoregulation and matrix metalloproteinase (MMP)-mediated extracellular matrix (ECM) remodeling. We revealed that microencapsulation activates the MAPK signaling pathway in MSCs to increase MMP expression, thereby degrading overexpressed collagen accumulated in fibrotic lungs. Our research demonstrates the potential of hydrogel microcapsules to enhance the therapeutic efficacy of MSCs through cell-material interactions, presenting a promising yet straightforward strategy for designing advanced stem cell therapies for fibrotic diseases.
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