茄丝核菌
镰刀菌
索拉尼镰刀菌
化学
三唑酮
抗真菌
立体化学
杀菌剂
微生物学
生物
植物
作者
Lulu Wu,Lijun Shi,Liangxin Fan,Zhenliang Pan,Zhonglin Zhao,Hui Su,Sheng Wang,Nan Yang,Cuilian Xu,Guoyu Yang
标识
DOI:10.1002/cbdv.202401052
摘要
A series of diversified glucosamine derivatives (3a‐3y) was synthesized and their antifungal activity was examined against four kinds of phytopathogens, Fusarium graminearum (F. graminearum), Fusarium moniliforme (F. moniliforme), Curvularia. lunata (C. lunata), and Rhizoctonia solani (R. solani)which cause seriously economic losses worldwide by affecting crops. The compound 3o showed remarkable antifungal activity against F. graminearum with EC50 values of 3.96 μg/mL, compared to the standard drug triadimefon (10.1μg/mL). 3D‐QSAR model with the statistically recommended values (r2 = 0.915, q2=0.872) show that positive charge group and bulky group in the benzyl ring were favorable for the antifungal activity. Enzyme activity assays confirmed that 3o has amoderate inhibition of trehalase with inhibition rate of 51.4%at 5 μg/mL, which is comparable to those of commercial inhibitors validamycin A with inhibition rate of 83.3%.Molecular docking analysis revealed that 3o also had a hydrogen bond interaction with key amino acid residue compared to validoxylamine.
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