Risk Factors and Treatment Strategies for Local Recurrence of Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy Followed by Total Mesorectal Excision

Despite advancements in total mesorectal excision (TME) and neoadjuvant radiotherapy, locally advanced rectal cancer remains challenging, impacting patient quality of life and mortality. This study aimed to identify the risk factors for local recurrence in locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (CRT) and assess treatment strategies for recurrence.