生物
脊椎动物
降钙素
进化生物学
动物
细胞生物学
内分泌学
遗传学
基因
作者
Jenaid Rees,Karen E. Kirk,Giacomo Gattoni,Dorit Hockman,Victoria A. Sleight,Dylan J. Ritter,Inna Dubchak,Ela W. Knapik,J. Gage Crump,Péter Fábián,J. Andrew Gillis
出处
期刊:Development
[The Company of Biologists]
日期:2024-08-07
卷期号:151 (20)
摘要
Vertebrate calcitonin-producing cells (C-cells) are neuroendocrine cells that secrete the small peptide hormone calcitonin in response to elevated blood calcium levels. Whereas mouse C-cells reside within the thyroid gland and derive from pharyngeal endoderm, avian C-cells are located within ultimobranchial glands and have been reported to derive from the neural crest. We use a comparative cell lineage tracing approach in a range of vertebrate model systems to resolve the ancestral embryonic origin of vertebrate C-cells. We find, contrary to previous studies, that chick C-cells derive from pharyngeal endoderm, with neural crest-derived cells instead contributing to connective tissue intimately associated with C-cells in the ultimobranchial gland. This endodermal origin of C-cells is conserved in a ray-finned bony fish (zebrafish) and a cartilaginous fish (the little skate, Leucoraja erinacea). Furthermore, we discover putative C-cell homologs within the endodermally-derived pharyngeal epithelium of the ascidian Ciona intestinalis and the amphioxus Branchiostoma lanceolatum, two invertebrate chordates that lack neural crest cells. Our findings point to a conserved endodermal origin of C-cells across vertebrates and to a pre-vertebrate origin of this cell type along the chordate stem.
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