The aqueous humour dynamics in primary angle closure disease: a computational study

计算流体力学 多物理 机械 医学 眼压 房水 生物医学工程 模拟 眼科 有限元法 计算机科学 结构工程 物理 工程类
作者
Лин Фу,Xinyi Liu,Longqian Zhang,Jiangtao Lou,Xiaobo Zheng,Xiaojue Wang,Haishuang Lin,Liang Guo,Kezhao Wang,Yan Wang,Min‐Yen Kan,Yuanbo Liang
出处
期刊:British Journal of Ophthalmology [BMJ]
卷期号:: bjo-325109
标识
DOI:10.1136/bjo-2023-325109
摘要

Purpose To create a computational fluid dynamics (CFD) model of ocular anterior segment for primary angle closure diseases (PACD) and assess the aqueous humour (AH) dynamics in different angle closure ranges (ACRs). Methods The ocular anterior segment geometry was obtained from an optical coherence tomography image by SOLIDWORKS. Three different angle opening distance at 750 µm from the scleral spur (AOD750) values were established to mimic three widths of anterior chamber angle. The AH dynamics were modelled using the Navier-Stokes equation. The 3D CFD model of the ocular anterior segment was created in COMSOL Multiphysics. The major outcome was the maximum flow velocity (MFV) and pressure in the ocular anterior segment. An in vitro simulation model was used to validate the computational results of the pressure and ACRs. Results The MFV and pressure both showed a non-linear association with ACR in the CFD models of PACD. The MFV and pressure started to elevate when ACR was larger than 180°, and increased dramatically when the ACR was larger than 270°. The in vitro experiment of the pressure changes was consistent with the CFD model. No significant differences of the MFV and pressure among the three AOD750 models. Conclusions The association among the ACR, MFV and pressure is an ascending curve in PACD, and ACR of 180° and 270° are two critical turning points. Our results are consistent with clinical phenomenon and may be used to provide better guidances for the clinical management of PACD in different stages.
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