Vascular graft infections (VGI) pose a significant challenge in vascular surgery, characterized by substantial morbidity and mortality. This review delves into the epidemiology, pathogenesis, microbiology, risk factors, and clinical presentation of VGI. It highlights diagnostic criteria and methodologies, including imaging techniques and laboratory tests. Comprehensive management strategies, involving antimicrobial therapy, surgical intervention, and preventive measures, are discussed. Emphasis is placed on the multidisciplinary approach required for effective treatment, alongside emerging trends in VGI microbiology and innovative therapeutic options. This review article aims to provide a detailed understanding of VGI for improved clinical outcomes.