消化(炼金术)
发酵
多糖
化学
体内
食品科学
果聚糖
白茅屬
粪便
胃肠道
生物利用度
生物化学
体外
生物
微生物学
色谱法
植物
生物技术
药理学
蔗糖
作者
Wenchen Yu,Junwen Wang,Yi Xiong,Jia‐Ren Liu,Denis Baranenko,Yingchun Zhang,Weihong Lu
标识
DOI:10.1016/j.foodchem.2024.140773
摘要
Recently we have investigated polysaccharide from Imperata cylindrica (ICP) for its physicochemical structure and biological activities. However, the digestion characteristics have yet to be understood. This study investigated the digestion and metabolism characteristics of ICP through in vivo fluorescence tracking, in vitro simulated digestion, fecal fermentation experiments, and microbial sequencing. The results showed that ICP significant distribution in the gastrointestinal tract and kidneys. ICP underwent slight degradation during simulated gastric and intestinal digestion. During fecal fermentation, the utilization degree of ICP and the concentration of short-chain fatty acids (SCFAs) increased. ICP promoted the increase of beneficial microbial abundance. To understand the impact of ICP on the integrity and health of intestinal tissues, molecular docking was employed to preliminarily predict the interaction between ICP and key proteins. The results revealed that ICP could recognize and bind to key proteins through high-affinity targeting binding sites.
科研通智能强力驱动
Strongly Powered by AbleSci AI