内质网
连接(主束)
肿瘤微环境
网
细胞生物学
压力(语言学)
生物
化学
癌症研究
肿瘤细胞
工程类
机械工程
哲学
语言学
作者
Hery Urra,Raúl Aravena,Lucas González-Johnson,Claudio Hetz
标识
DOI:10.1016/j.trecan.2024.09.011
摘要
The tumor microenvironment (TME) represents a dynamic network of cancer cells, stromal cells, immune mediators, and extracellular matrix components, crucial for cancer progression. Stress conditions such as oncogene activation, nutrient deprivation, and hypoxia disrupt the endoplasmic reticulum (ER), activating the unfolded protein response (UPR), the main adaptive mechanism to restore ER function. The UPR regulates cancer progression by engaging cell-autonomous and cell-non-autonomous mechanisms, reprogramming the stroma and promoting immune evasion, angiogenesis, and invasion. This review explores the role of UPR beyond cancer cells, focusing on how ER stress signaling reshapes the TME, supporting tumor growth. The therapeutic potential of targeting the UPR is also discussed.
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