化学
催化作用
曼尼希反应
有机化学
组合化学
对映选择合成
立体化学
作者
Akira Saito,Masakatsu Shibasaki
标识
DOI:10.1021/acs.orglett.4c02505
摘要
An asymmetric Mannich-type addition of aldimines and haloacetonitriles is reported here, yielding halogenated aminonitriles with excellent stereoselectivity, facilitated by a pincer Ni(II) complex as a catalyst. Haloacetonitriles are recognized as reactive electrophiles, and the possibility of their use as a pronucleophile has been almost neglected for many years. The resulting adduct can be readily converted into various valuable derivatives, including chiral aziridines, starting from chlorinated compounds.
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