氢氰酸
光延反应
羟醛反应
化学
硅烷化
试剂
立体选择性
组合化学
有机化学
叠氮化物
催化作用
作者
Cheng‐Kun Lin,Yi Chou,Xin‐Shun Chiou,Po‐Yu Tseng
标识
DOI:10.1002/slct.202300467
摘要
Abstract This method offers several advantages over traditional methods for the asymmetric synthesis of β ‐azido esters. First, the use of N ‐acetyl camphorsultam allows for excellent stereoselectivity in the aldol reaction, which is crucial for the subsequent Mitsunobu reaction. Second, the use of trimethylsilyl azide (TMSN 3 ) instead of hydrazoic acid (HN 3 ) eliminates the need for handling a highly toxic and explosive reagent, making the process safer and easier to carry out. Third, the use of basic conditions for the Mitsunobu reaction allows for the reaction to proceed efficiently without the formation of the undesired silyl ethers.
科研通智能强力驱动
Strongly Powered by AbleSci AI