活性氧
免疫系统
心脏移植
巨噬细胞
炎症
免疫学
获得性免疫系统
癌症研究
移植
医学
内科学
细胞生物学
生物
体外
生物化学
作者
Xingyu Lu,Zhanxue Xu,Fan Shu,Yidan Wang,Yuhang Han,Jing Wang,Peilin Shi,Fan Chuan-qiang,Li Wang,Fei Yu,Qipeng Sun,Fang Cheng,Hongbo Chen
标识
DOI:10.1002/adma.202406758
摘要
Heart transplantation offers life-saving treatment for patients with end-stage heart failure; however, ischemia-reperfusion injury (IRI) and subsequent immune responses remain significant challenges. Current therapies primarily target adaptive immunity, with limited options available for addressing IRI and innate immune activation. Although plant-derived vesicle-like nanoparticles show promise in managing diseases, their application in organ transplantation complications is unexplored. Here, this work develops a novel reactive oxygen species (ROS)-responsive multifunctional fusion extracellular nanovesicles carrying rapamycin (FNVs@RAPA) to address early IRI and Ly6C
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