免疫系统
肿瘤微环境
免疫抑制
癌症研究
修剪
医学
光热治疗
癌症
免疫学
内科学
纳米技术
材料科学
计算机科学
操作系统
作者
Yuanlin Wang,Yaqian Han,Chenhui Yang,Tiancheng Bai,Chenggang Zhang,Zhaotong Wang,Ye Sun,Ying Hu,Flemming Besenbacher,Chunying Chen,Miao Yu
标识
DOI:10.1038/s41467-024-48662-x
摘要
Abstract The role of tumor-resident intracellular microbiota (TRIM) in carcinogenesis has sparked enormous interest. Nevertheless, the impact of TRIM-targeted antibacteria on tumor inhibition and immune regulation in the tumor microenvironment (TME) remains unexplored. Herein, we report long-term relapse-free survival by coordinating antibacteria with antitumor treatment, addressing the aggravated immunosuppression and tumor overgrowth induced by TRIM using breast and prostate cancer models. Combining Ag + release with a Fenton-like reaction and photothermal conversion, simultaneous bacteria killing and multimodal antitumor therapy are enabled by a single agent. Free of immune-stimulating drugs, the agent restores antitumor immune surveillance and activates immunological responses. Secondary inoculation and distal tumor analysis confirm lasting immunological memory and systemic immune responses. A relapse-free survival of >700 days is achieved. This work unravels the crucial role of TRIM-targeted antibacteria in tumor inhibition and unlocks an unconventional route for immune regulation in TME and a complete cure for cancer.
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