马尔科夫尼科夫法则
氢酰化
化学
芳基
催化作用
钴
组合化学
基质(水族馆)
原子经济
有机化学
区域选择性
醛
海洋学
地质学
烷基
作者
Guanghao Ji,Xuan Li,J. Zhang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-12-28
卷期号:27 (1): 334-339
被引量:3
标识
DOI:10.1021/acs.orglett.4c04373
摘要
Herein we describe a dual photo/cobalt-catalyzed anti-Markovnikov hydroacylation of aryl alkenes using aldehyde as acyl source. The key to success is the cobalt catalyzed hydrogen atom transfer, which enables effective formation of the desired products and efficient regeneration of the photocatalyst under mild conditions. This protocol features broad substrate scopes, good functional group tolerance, high efficiency and regioselectivity.
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