Low-density lipoprotein cholesterol predicts coronary artery calcification events in patients with type 2 diabetes: a longitudinal study

医学 内科学 糖尿病 2型糖尿病 心脏病学 胆固醇 钙化 冠状动脉疾病 内分泌学
作者
Zhiyong Zou,Yongbing Sun,Lijun Zou,Yang Zhou,Xinbei Lin,Jing Zhou,Zhonglin Li,Xiao-Ling Wu,Ling Wang,Xiaodong Li,Yong Wang,Yangxi Hu,Fengli Li,Jiancheng Zhang,Yongli Li
出处
期刊:Diabetology & Metabolic Syndrome [BioMed Central]
卷期号:17 (1)
标识
DOI:10.1186/s13098-025-01625-8
摘要

Coronary Artery Calcification (CAC) is a major risk factor for various cardiovascular diseases. Low-Density Lipoprotein Cholesterol (LDL-C) is a significant factor in atherosclerotic cardiovascular diseases and is usually elevated in patients with Type 2 Diabetes Mellitus (T2DM). However, the association between LDL-C levels and incident CAC in asymptomatic T2DM patients remains unclear. This study is a single-center retrospective cohort study conducted from January 2018 to December 2023, including 2,631 asymptomatic T2DM patients who underwent regular health screenings. All participants were confirmed to be free of CAC at baseline by computed tomography (CT). Based on baseline LDL-C levels, participants were divided into three groups (T1: 0.66–2.43 mmol/L; T2: 2.44–3.18 mmol/L; T3: 3.19–7.21 mmol/L). The follow-up endpoint was the occurrence of incident CAC, with a total follow-up period of 72 months. Kaplan-Meier survival curves were used for analysis, followed by log-rank tests. Univariate and multivariate Cox proportional hazards regression models were employed to investigate the relationship between LDL-C and incident CAC, and subgroup analysis was performed to test the robustness of the LDL-C and CAC relationship. During a median follow-up period of 29.9 months, 885 (33.64%) participants developed incident CAC occurred. The cumulative incidence of incident CAC increased progressively with higher LDL-C levels (log-rank test, P < 0.001). After adjusting for confounding factors, multivariable Cox proportional hazards regression results showed a significant association between LDL-C and incident CAC (hazard ratio [HR], 1.77; 95% confidence interval [CI], 1.64–1.92). When LDL-C was treated as a categorical variable, elevated levels in T2 (adjusted HR, 1.62; 95% CI, 1.36–1.93; P < 0.001) and T3 (adjusted HR, 3.38; 95% CI, 2.84–4.03; P < 0.001) were significantly associated with the risk of incident CAC. Additionally, subgroup analysis demonstrated a consistent association between LDL-C and incident CAC. High LDL-C levels are associated with incident CAC in asymptomatic T2DM patients, suggesting that LDL-C may be useful for risk stratification in this population.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
上官若男应助崔噔噔采纳,获得10
刚刚
sl发布了新的文献求助10
1秒前
Amb1tionG完成签到,获得积分10
2秒前
小张完成签到 ,获得积分10
2秒前
995完成签到 ,获得积分10
2秒前
烂漫的衬衫完成签到,获得积分10
3秒前
joybee完成签到,获得积分0
3秒前
4秒前
开心谷秋完成签到,获得积分10
6秒前
soss完成签到,获得积分10
6秒前
8秒前
缓慢醉卉发布了新的文献求助10
8秒前
Honey完成签到,获得积分10
9秒前
iceice完成签到,获得积分10
9秒前
壮观的谷冬完成签到 ,获得积分0
12秒前
和谐曼凝完成签到 ,获得积分10
15秒前
如意竺完成签到,获得积分10
15秒前
fzd完成签到,获得积分10
17秒前
20秒前
livra1058完成签到,获得积分10
21秒前
HAO完成签到,获得积分10
23秒前
震动的沉鱼完成签到 ,获得积分10
24秒前
糕糕发布了新的文献求助40
25秒前
dyk完成签到,获得积分10
25秒前
27秒前
carryxu完成签到,获得积分10
27秒前
卡卡罗特应助谦让小蚂蚁采纳,获得10
27秒前
大个应助缓慢醉卉采纳,获得10
28秒前
lzhgoashore完成签到,获得积分10
28秒前
28秒前
helpme完成签到,获得积分10
28秒前
DLY完成签到,获得积分10
29秒前
30秒前
30秒前
达笙完成签到 ,获得积分10
31秒前
研友_VZG7GZ应助炒鸡小将采纳,获得10
33秒前
闪闪山柳完成签到 ,获得积分10
33秒前
在水一方应助科研通管家采纳,获得10
34秒前
小二郎应助科研通管家采纳,获得10
34秒前
852应助科研通管家采纳,获得10
34秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038426
求助须知:如何正确求助?哪些是违规求助? 3576119
关于积分的说明 11374556
捐赠科研通 3305834
什么是DOI,文献DOI怎么找? 1819339
邀请新用户注册赠送积分活动 892678
科研通“疑难数据库(出版商)”最低求助积分说明 815029