Variables associated with cognitive function: an exposome-wide and mendelian randomization analysis

孟德尔随机化 认知 单变量 医学 临床心理学 心理学 精神科 生物 多元统计 遗传学 统计 数学 遗传变异 基因型 基因
作者
Yongli Zhao,Yizhe Hao,Yi‐Jun Ge,Yi Zhang,Liu‐Ye Huang,Yan Fu,Dandan Zhang,Ya‐Nan Ou,Xi‐Peng Cao,Jianfeng Feng,Wei Cheng,Lan Tan,Jin-Tai Yu
出处
期刊:Alzheimer's Research & Therapy [BioMed Central]
卷期号:17 (1) 被引量:2
标识
DOI:10.1186/s13195-025-01670-5
摘要

Evidence indicates that cognitive function is influenced by potential environmental factors. We aimed to determine the variables influencing cognitive function. Our study included 164,463 non-demented adults (89,644 [54.51%] female; mean [SD] age, 56.69 [8.14] years) from the UK Biobank who completed four cognitive assessments at baseline. 364 variables were finally extracted for analysis through a rigorous screening process. We performed univariate analyses to identify variables significantly associated with each cognitive function in two equal-sized split discovery and replication datasets. Subsequently, the identified variables in univariate analyses were further assessed in a multivariable model. Additionally, for the variables identified in multivariable model, we explored the associations with longitudinal cognitive decline. Moreover, one- and two- sample Mendelian randomization (MR) analyses were conducted to confirm the genetic associations. Finally, the quality of the pooled evidence for the associations between variables and cognitive function was evaluated. 252 variables (69%) exhibited significant associations with at least one cognitive function in the discovery dataset. Of these, 231 (92%) were successfully replicated. Subsequently, our multivariable analyses identified 41 variables that were significantly associated with at least one cognitive function, spanning categories such as education, socioeconomic status, lifestyle factors, body measurements, mental health, medical conditions, early life factors, and household characteristics. Among these 41 variables, 12 were associated with more than one cognitive domain, and were further identified in all subgroup analyses. And LASSO, rigde, and principal component analysis indicated the robustness of the primary results. Moreover, among these 41 variables, 12 were significantly associated with a longitudinal cognitive decline. Furthermore, 22 were supported by one-sample MR analysis, and 5 were further confirmed by two-sample MR analysis. Additionally, the quality of the pooled evidence for the associations between 10 variables and cognitive function was rated as high. Based on these 10 identified variables, adopting a more favorable lifestyle was significantly associated with 38% and 34% decreased risks of dementia and Alzheimer's disease (AD). Overall, our study constructed an evidence database of variables associated with cognitive function, which could contribute to the prevention of cognitive impairment and dementia.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
IRer79发布了新的文献求助10
刚刚
量子星尘发布了新的文献求助10
刚刚
麦丰完成签到,获得积分10
刚刚
刚刚
likke完成签到,获得积分20
1秒前
1秒前
FashionBoy应助li采纳,获得10
2秒前
2秒前
SciGPT应助薛定谔的猫采纳,获得10
2秒前
3秒前
3秒前
muming完成签到,获得积分20
4秒前
sanlunainiu发布了新的文献求助10
4秒前
林博研完成签到,获得积分20
4秒前
FashionBoy应助风趣的灵枫采纳,获得10
5秒前
6秒前
yihuiqing发布了新的文献求助10
7秒前
likke发布了新的文献求助10
7秒前
嗝嗝发布了新的文献求助10
7秒前
小兔狸花昕完成签到,获得积分20
8秒前
IRer79完成签到,获得积分10
10秒前
彭于晏应助noah采纳,获得10
10秒前
青年才俊发布了新的文献求助10
10秒前
zhu发布了新的文献求助10
11秒前
波波蛋完成签到,获得积分10
11秒前
12秒前
13秒前
14秒前
maguodrgon发布了新的文献求助10
17秒前
科研通AI5应助shell采纳,获得80
17秒前
波波蛋发布了新的文献求助10
17秒前
18秒前
九鹤完成签到,获得积分10
18秒前
jsy完成签到,获得积分10
18秒前
量子星尘发布了新的文献求助10
19秒前
旷野发布了新的文献求助10
19秒前
19秒前
Owen应助浮云521采纳,获得10
19秒前
浮游应助muming采纳,获得10
19秒前
酷炫的凤妖完成签到 ,获得积分10
20秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zeolites: From Fundamentals to Emerging Applications 1500
Architectural Corrosion and Critical Infrastructure 1000
Early Devonian echinoderms from Victoria (Rhombifera, Blastoidea and Ophiocistioidea) 1000
By R. Scott Kretchmar - Practical Philosophy of Sport and Physical Activity - 2nd (second) Edition: 2nd (second) Edition 666
Energy-Size Reduction Relationships In Comminution 500
Principles Of Comminution, I-Size Distribution And Surface Calculations 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4941339
求助须知:如何正确求助?哪些是违规求助? 4207390
关于积分的说明 13077624
捐赠科研通 3986257
什么是DOI,文献DOI怎么找? 2182529
邀请新用户注册赠送积分活动 1198125
关于科研通互助平台的介绍 1110387