无血性
渴求
阿片类药物使用障碍
心理学
线索反应性
临床心理学
前额叶皮质
愉快
精神科
联想(心理学)
精神分裂症(面向对象编程)
类阿片
上瘾
神经科学
医学
内科学
认知
心理治疗师
受体
作者
Daniel Petrie,Kyler S. Knapp,Christopher S. Freet,Erin Deneke,Timothy R. Brick,H. Harrington Cleveland,Scott C. Bunce
标识
DOI:10.1016/j.brainresbull.2022.09.012
摘要
Both anhedonia and craving are common among patients with opioid use disorder (OUD), and are associated with vulnerability to relapse. Although these constructs are theoretically linked relatively few studies have examined them together. In the current study, recently withdrawn patients (N = 71) in residential treatment for prescription OUD underwent a cue reactivity paradigm while being monitored with functional near-infrared spectroscopy (fNIRS). Patients also self-reported symptoms of anhedonia via the Snaith-Hamilton Pleasure Scale (SHAPS), while smartphone-based ecological momentary assessments (EMA) were used to measure craving levels. On average, lower right prefrontal cortex (PFC) activity in response to positive social stimuli was associated with higher craving (β = - 2.87; S.E. = 1.23; p = 0.02). Self-reported anhedonia moderated the association between PFC activity and craving (β = - 1.02; S.E. = 0.48; p = 0.04), such that patients with two or more anhedonic symptoms had a significant and stronger negative association between PFC activation to hedonically positive images and craving, compared to patients with fewer than two anhedonic symptoms, among whom the association was not significant. This finding provides evidence that higher levels of anhedonia among patients in residential treatment for OUD are associated with a stronger link between lower PFC response to positive social experiences and higher levels of craving, potentially increasing overall vulnerability to relapse.
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