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Prefrontal cortical response to natural rewards and self-reported anhedonia are associated with greater craving among recently withdrawn patients in residential treatment for opioid use disorder

无血性 渴求 阿片类药物使用障碍 心理学 线索反应性 临床心理学 前额叶皮质 愉快 精神科 联想(心理学) 精神分裂症(面向对象编程) 类阿片 上瘾 神经科学 医学 内科学 认知 心理治疗师 受体
作者
Daniel Petrie,Kyler S. Knapp,Christopher S. Freet,Erin Deneke,Timothy R. Brick,H. Harrington Cleveland,Scott C. Bunce
出处
期刊:Brain Research Bulletin [Elsevier]
卷期号:190: 32-41 被引量:3
标识
DOI:10.1016/j.brainresbull.2022.09.012
摘要

Both anhedonia and craving are common among patients with opioid use disorder (OUD), and are associated with vulnerability to relapse. Although these constructs are theoretically linked relatively few studies have examined them together. In the current study, recently withdrawn patients (N = 71) in residential treatment for prescription OUD underwent a cue reactivity paradigm while being monitored with functional near-infrared spectroscopy (fNIRS). Patients also self-reported symptoms of anhedonia via the Snaith-Hamilton Pleasure Scale (SHAPS), while smartphone-based ecological momentary assessments (EMA) were used to measure craving levels. On average, lower right prefrontal cortex (PFC) activity in response to positive social stimuli was associated with higher craving (β = - 2.87; S.E. = 1.23; p = 0.02). Self-reported anhedonia moderated the association between PFC activity and craving (β = - 1.02; S.E. = 0.48; p = 0.04), such that patients with two or more anhedonic symptoms had a significant and stronger negative association between PFC activation to hedonically positive images and craving, compared to patients with fewer than two anhedonic symptoms, among whom the association was not significant. This finding provides evidence that higher levels of anhedonia among patients in residential treatment for OUD are associated with a stronger link between lower PFC response to positive social experiences and higher levels of craving, potentially increasing overall vulnerability to relapse.

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