Design and catalytic atroposelective synthesis of axially chiral isochromenone-indoles

The catalytic atroposelective synthesis of axially chiral isochromenone-indoles has been established by the strategy of designing homophthalic anhydride-based indole derivatives as a new type of indole-based platform molecules for dynamic kinetic resolution. By this strategy, a wide range of axially chiral isochromenone-indoles were synthesized in high yields with excellent enantioselectivities (up to 98% yield, 97% ee) via the catalytic asymmetric sulfonylation reaction of homophthalic anhydride-based indole derivatives with aryl sulfonyl chlorides under the catalysis of chiral quaternary ammonium salt as a phase-transfer catalyst