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Plasma miR-124-3p and miR-16 concentrations as prognostic markers in acute stroke

医学 内科学 冲程(发动机) 急性中风 心脏病学 肿瘤科 机械工程 工程类 组织纤溶酶原激活剂
作者
Timothy H. Rainer,Ling Yan Leung,Cangel Pui Yee Chan,Yuk Ki Leung,Jill Abrigo,Defeng Wang,Colin A. Graham
出处
期刊:Clinical Biochemistry [Elsevier BV]
卷期号:49 (9): 663-668 被引量:40
标识
DOI:10.1016/j.clinbiochem.2016.02.016
摘要

This study aimed to investigate plasma concentrations of miR-124-3p and miR-16 as prognostic markers in emergency department patients with acute stroke. Plasma concentrations of miR-124-3p and miR-16 of 84 stroke patients (presenting to the emergency department within 24 h from onset of symptoms) were determined by RT-qPCR. The primary outcome measure was 3-month mortality and the secondary outcome measure was post-stroke modified Rankin Score (mRS). Twelve patients (14.3%) died within 3 months of hospital admission and forty-one (48.8%) patients as achieved a 3-month mRS > 2. Median plasma miR-124-3p concentrations were elevated in patients who died compared to patients who survived (p = 0.0052), and its levels were found to be higher in patients with a 3-month mRS > 2 compared with patients with mRS ≤ 2 (p = 0.0312). Higher plasma miR-16 concentrations were observed in patients who survived than in patients who died (p = 0.0394), while its concentrations were lower in patients achieving mRS > 2 than in patients with mRS ≤ 2 (p = 0.0124). For a subgroup of cases presenting to the emergency department within 6 h from time of symptom onset (n = 36), plasma miR-124-3p concentrations predicted 3-month mortality with an area under the ROC curve of 0.87 (95%CI: 0.72–0.96). Plasma miR-124-3p and miR-16 are molecular markers which could be useful for the early prediction of mortality and mRS.
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