少突胶质细胞
白质
奥利格2
髓鞘
前额叶皮质
神经科学
心理学
重性抑郁障碍
磁共振弥散成像
生物
髓鞘碱性蛋白
胼胝体
内科学
内分泌学
中枢神经系统
磁共振成像
医学
扁桃形结构
认知
放射科
作者
Grażyna Rajkowska,Gouri Mahajan,Dorota Maciąg,Monica Sathyanesan,Abiye H. Iyo,Mohadetheh Moulana,Patrick B. Kyle,William L. Woolverton,José Javier Miguel-Hidalgo,Craig A. Stockmeier,Samuel S. Newton
标识
DOI:10.1016/j.jpsychires.2015.04.010
摘要
White matter disturbance in the ventral prefrontal cortex (vPFC) in major depressive disorder (MDD) has been noted with diffusion tensor imaging (DTI). However, the cellular and molecular pathology of prefrontal white matter in MDD and potential influence of antidepressant medications is not fully understood. Oligodendrocyte morphometry and myelin-related mRNA and protein expression was examined in the white matter of the vPFC in MDD. Sections of deep and gyral white matter from the vPFC were collected from 20 subjects with MDD and 16 control subjects. Density and size of CNPase-immunoreactive (-IR) oligodendrocytes were estimated using 3-dimensional cell counting. While neither density nor soma size of oligodendrocytes was significantly affected in deep white matter, soma size was significantly decreased in the gyral white matter in MDD. In rhesus monkeys treated chronically with fluoxetine there was no significant effect on oligodendrocyte morphometry. Using quantitative RT-PCR to measure oligodendrocyte-related mRNA for CNPase, PLP1, MBP, MOG, MOBP, Olig1 and Olig2, in MDD there was a significantly reduced expression of PLP1 mRNA (which positively correlated with smaller sizes) and increased expression of mRNA for CNPase, OLIG1 and MOG. The expression of CNPase protein was significantly decreased in MDD. Altered expression of four myelin genes and CNPase protein suggests a mechanism for the degeneration of cortical axons and dysfunctional maturation of oligodendrocytes in MDD. The change in oligodendrocyte morphology in gyral white matter may parallel altered axonal integrity as revealed by DTI.
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