Antitumor Immunity Induced after α Irradiation

免疫原性细胞死亡 免疫系统 癌症研究 免疫原性 获得性免疫系统 免疫 放射免疫疗法 放射生物学 生物 免疫学 免疫疗法 医学 放射治疗 抗体 单克隆抗体 内科学
作者
Jean‐Baptiste Gorin,Jérémie Ménager,Sébastien Gouard,Catherine Maurel,Yannick Guilloux,Alain Faivre-Chauvet,Aliyah Morgenstern,Frank Bruchertseifer,Michel Chérel,François Davodeau,Joëlle Gaschet
出处
期刊:Neoplasia [Elsevier BV]
卷期号:16 (4): 319-328 被引量:82
标识
DOI:10.1016/j.neo.2014.04.002
摘要

Radioimmunotherapy (RIT) is a therapeutic modality that allows delivering of ionizing radiation directly to targeted cancer cells. Conventional RIT uses β-emitting radioisotopes, but recently, a growing interest has emerged for the clinical development of α particles. α emitters are ideal for killing isolated or small clusters of tumor cells, thanks to their specific characteristics (high linear energy transfer and short path in the tissue), and their effect is less dependent on dose rate, tissue oxygenation, or cell cycle status than γ and X rays. Several studies have been performed to describe α emitter radiobiology and cell death mechanisms induced after α irradiation. But so far, no investigation has been undertaken to analyze the impact of α particles on the immune system, when several studies have shown that external irradiation, using γ and X rays, can foster an antitumor immune response. Therefore, we decided to evaluate the immunogenicity of murine adenocarcinoma MC-38 after bismuth-213 (213Bi) irradiation using a vaccination approach. In vivo studies performed in immunocompetent C57Bl/6 mice induced a protective antitumor response that is mediated by tumor-specific T cells. The molecular mechanisms potentially involved in the activation of adaptative immunity were also investigated by in vitro studies. We observed that 213Bi-treated MC-38 cells release "danger signals" and activate dendritic cells. Our results demonstrate that α irradiation can stimulate adaptive immunity, elicits an efficient antitumor protection, and therefore is an immunogenic cell death inducer, which provides an attractive complement to its direct cytolytic effect on tumor cells.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
如梦如画完成签到 ,获得积分10
刚刚
华仔应助科研通管家采纳,获得10
刚刚
accepted应助科研通管家采纳,获得10
1秒前
accepted应助科研通管家采纳,获得10
1秒前
1秒前
1秒前
wanci应助科研通管家采纳,获得10
1秒前
1秒前
1秒前
1秒前
ylw发布了新的文献求助10
1秒前
5High_0完成签到 ,获得积分10
2秒前
上官若男应助Zzz采纳,获得10
2秒前
bzg完成签到,获得积分20
5秒前
甜蜜的楷瑞应助王手采纳,获得10
6秒前
糖发人发布了新的文献求助10
6秒前
090完成签到,获得积分10
6秒前
chen发布了新的文献求助10
6秒前
Clyde完成签到,获得积分10
8秒前
8秒前
和谐续完成签到 ,获得积分10
9秒前
大个应助李皓婷采纳,获得10
9秒前
11秒前
chen完成签到,获得积分10
11秒前
Hello应助ylw采纳,获得10
11秒前
12秒前
ChemistryZyh发布了新的文献求助10
12秒前
wensir发布了新的文献求助10
12秒前
端庄千琴完成签到,获得积分10
12秒前
heavennew完成签到,获得积分10
13秒前
14秒前
眼睛大樱桃完成签到,获得积分10
14秒前
Yuantian发布了新的文献求助10
15秒前
学吗你完成签到 ,获得积分10
15秒前
御青白少发布了新的文献求助10
16秒前
无尽夏完成签到,获得积分10
16秒前
Rylee发布了新的文献求助10
18秒前
18秒前
无私的念文完成签到 ,获得积分10
19秒前
充电宝应助Yuantian采纳,获得10
20秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048