亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Heritability of Autism Spectrum Disorder in a UK Population-Based Twin Sample

自闭症 自闭症谱系障碍 孤独症诊断观察量表 人口 遗传力 双胞胎研究 心理学 队列 范畴变量 医学 发展心理学 统计 遗传学 生物 环境卫生 内科学 数学
作者
Emma Colvert,Beata Tick,Fiona McEwen,Catherine Stewart,Sarah Curran,Emma Woodhouse,Nicola Gillan,Victoria Hallett,Stephanie Lietz,Tracy Garnett,Angelica Ronald,Robert Plomin,Frühling Rijsdijk,Francesca Happé,Patrick Bolton
出处
期刊:JAMA Psychiatry [American Medical Association]
卷期号:72 (5): 415-415 被引量:375
标识
DOI:10.1001/jamapsychiatry.2014.3028
摘要

Importance

Most evidence to date highlights the importance of genetic influences on the liability to autism and related traits. However, most of these findings are derived from clinically ascertained samples, possibly missing individuals with subtler manifestations, and obtained estimates may not be representative of the population.

Objectives

To establish the relative contributions of genetic and environmental factors in liability to autism spectrum disorder (ASD) and a broader autism phenotype in a large population-based twin sample and to ascertain the genetic/environmental relationship between dimensional trait measures and categorical diagnostic constructs of ASD.

Design, Setting, and Participants

We used data from the population-based cohort Twins Early Development Study, which included all twin pairs born in England and Wales from January 1, 1994, through December 31, 1996. We performed joint continuous-ordinal liability threshold model fitting using the full information maximum likelihood method to estimate genetic and environmental parameters of covariance. Twin pairs underwent the following assessments: the Childhood Autism Spectrum Test (CAST) (6423 pairs; mean age, 7.9 years), the Development and Well-being Assessment (DAWBA) (359 pairs; mean age, 10.3 years), the Autism Diagnostic Observation Schedule (ADOS) (203 pairs; mean age, 13.2 years), the Autism Diagnostic Interview–Revised (ADI-R) (205 pairs; mean age, 13.2 years), and a best-estimate diagnosis (207 pairs).

Main Outcomes and Measures

Participants underwent screening using a population-based measure of autistic traits (CAST assessment), structured diagnostic assessments (DAWBA, ADI-R, and ADOS), and a best-estimate diagnosis.

Results

On all ASD measures, correlations among monozygotic twins (range, 0.77-0.99) were significantly higher than those for dizygotic twins (range, 0.22-0.65), giving heritability estimates of 56% to 95%. The covariance of CAST and ASD diagnostic status (DAWBA, ADOS and best-estimate diagnosis) was largely explained by additive genetic factors (76%-95%). For the ADI-R only, shared environmental influences were significant (30% [95% CI, 8%-47%]) but smaller than genetic influences (56% [95% CI, 37%-82%]).

Conclusions and Relevance

The liability to ASD and a more broadly defined high-level autism trait phenotype in this large population-based twin sample derives primarily from additive genetic and, to a lesser extent, nonshared environmental effects. The largely consistent results across different diagnostic tools suggest that the results are generalizable across multiple measures and assessment methods. Genetic factors underpinning individual differences in autismlike traits show considerable overlap with genetic influences on diagnosed ASD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Owen应助獭兔采纳,获得10
7秒前
小学生的练习簿完成签到,获得积分0
8秒前
kmzzy完成签到,获得积分10
17秒前
19秒前
獭兔发布了新的文献求助10
23秒前
Jasper应助科研通管家采纳,获得10
34秒前
Hello应助科研通管家采纳,获得10
34秒前
獭兔完成签到,获得积分10
58秒前
1分钟前
wqc2060完成签到,获得积分10
1分钟前
FIN发布了新的文献求助50
2分钟前
sailingluwl完成签到,获得积分10
2分钟前
2分钟前
共享精神应助科研通管家采纳,获得10
2分钟前
慕青应助科研通管家采纳,获得10
2分钟前
Ava应助科研通管家采纳,获得10
2分钟前
小余同学完成签到,获得积分10
2分钟前
小余同学发布了新的文献求助10
2分钟前
CipherSage应助吴彦祖采纳,获得10
3分钟前
糊涂的青烟完成签到 ,获得积分10
3分钟前
wangye完成签到 ,获得积分10
3分钟前
3分钟前
3分钟前
吴彦祖发布了新的文献求助10
3分钟前
lyj完成签到 ,获得积分10
3分钟前
3分钟前
脑洞疼应助生动之云采纳,获得10
3分钟前
bji完成签到,获得积分10
3分钟前
大模型应助bji采纳,获得10
3分钟前
4分钟前
SciGPT应助科研通管家采纳,获得10
4分钟前
独特纸飞机完成签到 ,获得积分10
4分钟前
4分钟前
XQQDD完成签到,获得积分10
5分钟前
arsenal完成签到 ,获得积分10
5分钟前
zhouleiwang完成签到,获得积分10
5分钟前
5分钟前
5分钟前
FFFFcom完成签到,获得积分10
6分钟前
科研通AI2S应助科研通管家采纳,获得10
6分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513278
关于积分的说明 11167234
捐赠科研通 3248660
什么是DOI,文献DOI怎么找? 1794386
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804638