已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Phenotype of Frailty: Characterization in the Women's Health and Aging Studies

混淆 老年学 医学 内部有效性 制度化 虚弱综合征 日常生活活动 外部有效性 人口 临床心理学 心理学 虚弱指数 精神科 环境卫生 社会心理学 病理
作者
Karen Bandeen‐Roche,Qian‐Li Xue,Luigi Ferrucci,Jeremy Walston,Jack M. Guralnik,Paulo H. M. Chaves,Scott L. Zeger,Linda P. Fried
出处
期刊:The Journals of Gerontology [Oxford University Press]
卷期号:61 (3): 262-266 被引量:1145
标识
DOI:10.1093/gerona/61.3.262
摘要

"Frailty" is an adverse, primarily gerontologic, health condition regarded as frequent with aging and having severe consequences. Although clinicians claim that the extremes of frailty can be easily recognized, a standardized definition of frailty has proved elusive until recently. This article evaluates the cross-validity, criterion validity, and internal validity in the Women's Health and Aging Studies (WHAS) of a discrete measure of frailty recently validated in the Cardiovascular Health Study (CHS).The frailty measure developed in CHS was delineated in the WHAS data sets. Using latent class analysis, we evaluated whether criteria composing the measure aggregate into a syndrome. We verified the criterion validity of the measure by testing whether participants defined as frail were more likely than others to develop adverse geriatric outcomes or to die.The distributions of frailty in the WHAS and CHS were comparable. In latent class analyses, the measures demonstrated strong internal validity vis à vis stated theory characterizing frailty as a medical syndrome. In proportional hazards models, frail women had a higher risk of developing activities of daily living (ADL) and/or instrumental ADL disability, institutionalization, and death, independently of multiple potentially confounding factors.The findings of this study are consistent with the widely held theory that conceptualizes frailty as a syndrome. The frailty definition developed in the CHS is applicable across diverse population samples and identifies a profile of high risk of multiple adverse outcomes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
卡皮巴拉完成签到,获得积分10
1秒前
清爽源智完成签到,获得积分10
4秒前
6秒前
漂亮采波完成签到,获得积分10
7秒前
YamDaamCaa应助科研顺利啦采纳,获得50
8秒前
敏感的南露完成签到,获得积分10
10秒前
Nefelibata完成签到,获得积分10
11秒前
bystanding完成签到,获得积分10
11秒前
慕青应助zty123采纳,获得10
13秒前
彪壮的银耳汤完成签到 ,获得积分10
15秒前
轩辕山槐完成签到,获得积分10
21秒前
22秒前
zty123完成签到,获得积分10
24秒前
大树完成签到 ,获得积分10
26秒前
26秒前
干净思远完成签到,获得积分10
26秒前
zty123发布了新的文献求助10
28秒前
领导范儿应助漂亮采波采纳,获得10
29秒前
量子星尘发布了新的文献求助10
29秒前
zxy完成签到 ,获得积分10
29秒前
科研通AI2S应助科研通管家采纳,获得30
30秒前
30秒前
Akim应助科研通管家采纳,获得10
30秒前
30秒前
30秒前
30秒前
30秒前
30秒前
852应助科研通管家采纳,获得10
30秒前
Limerencia完成签到,获得积分10
31秒前
echo完成签到 ,获得积分10
33秒前
34秒前
36秒前
38秒前
土豆你个西红柿完成签到 ,获得积分10
39秒前
Doki发布了新的文献求助10
40秒前
芯之痕发布了新的文献求助10
41秒前
哔噗哔噗完成签到,获得积分10
43秒前
学霸宇大王完成签到 ,获得积分10
44秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976600
求助须知:如何正确求助?哪些是违规求助? 3520674
关于积分的说明 11204422
捐赠科研通 3257298
什么是DOI,文献DOI怎么找? 1798683
邀请新用户注册赠送积分活动 877842
科研通“疑难数据库(出版商)”最低求助积分说明 806595