微载波
自愈水凝胶
组织工程
再生医学
再生(生物学)
干细胞
生物相容性
药物输送
细胞包封
过程(计算)
生物医学工程
医学
细胞生物学
纳米技术
材料科学
细胞
化学
计算机科学
生物
操作系统
高分子化学
冶金
生物化学
标识
DOI:10.1080/14712598.2017.1256389
摘要
Organ dysfunction and failure are major health issues affecting millions of patients, many of whom are desperate for organ transplantation. Tissue regeneration aims at providing alternative solutions through innovative application of cell biology and materials engineering to clinical practice. Biomaterials play a critical role in tissue engineering, which interface with both cell biology and surgical procedures. Injectable stem cell carriers represent a promising platform to harvest the therapeutic effects of cells and to simplify the surgical process. Areas covered: This review is focused on injectable cell carriers which are not only expected to improve therapeutic outcomes, but also to facilitate easy surgical process. Such cell carriers include in situ gelling hydrogel, injectable supramolecular hydrogels, and microcarriers. Expert opinion: The current design of hydrogels and microcarriers can achieve biocompatibility, biodegradability, and provide desirable features to enhance biological response. Overall, more systematic understanding of stem cell behaviors in a synthetic microenvironment, as well as advancement in materials sciences, are needed to design injectable biomaterials that can provide all critical guidance for the full course of tissue regeneration.
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