Deheiculatins A-L, 20-oxygenated cembranoids from Macaranga deheiculata

Twelve cembranoids, deheiculatins A-L, were isolated from the leaves and twigs of Macaranga deheiculata. Their structures were elucidated on the basis of spectroscopic data. Five of these compounds displayed moderate inhibitory activity against human and/or mouse 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 20-Oxygenated cembranes are rare.