Neutrophil phenotypes in chronic lung disease

医学 慢性阻塞性肺病 表型 疾病 重症监护医学 专家意见 炎症 肺病 临床表型 免疫学 病理 内科学 遗传学 生物 基因
作者
Michael Hughes,Elizabeth Sapey,Robert A. Stockley
出处
期刊:Expert Review of Respiratory Medicine [Informa]
卷期号:13 (10): 951-967 被引量:18
标识
DOI:10.1080/17476348.2019.1654377
摘要

Introduction: Neutrophils are the most abundant inflammatory cells in the lungs of patients with chronic lung diseases, especially COPD, yet despite this, patients often experience repeated chest infections. Neutrophil function may be altered in disease, but the reasons are unclear. In chronic disease, sequential pro-inflammatory and pro-repair responses appear distorted. As understanding of neutrophil heterogeneity has expanded, it is suggested that different neutrophil phenotypes may impact on health and disease.Areas covered: In this review, the definition of cellular phenotype, the implication of neutrophil surface markers and functions in chronic lung disease and the complex influences of external, local and genetic factors on these changes are discussed. Literature was accessed up to the 19 July 2019 using: PubMed, US National Library of Medicine National Institutes of Health and the National Centre for Biotechnology Information.Expert opinion: As more is learned about neutrophils, the further we step from the classical view of neutrophils being unrefined killing machines to highly complex and finely tuned cells. Future therapeutics may aim to normalize neutrophil function, but to achieve this, knowledge of phenotypes in humans and how these relate to observed pathology and disease processes is required.
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