Introduction of Bicyclic Ketal Chemistry: Synthesis and Transformation Reaction of 6,8-Dioxabicyclo[3.2.1]octane Skeletal System

A stereo- and regioselective bicyclic ketal synthesis and several facile one-pot transformations of bicyclic ketals are described with plausible mechanisms. Products have included 6,£-unsaturated ketones, mono- and diacetoxy ketones, transketalized ketones, cis- and trans-cyclic ethers, 1,5-diketones, cis-1,2-cyclopentanediols, 2,6-disubstituted pyridines, 2,3,6-trisubstituted pyridines, and conjugated and nonconjugated cyclohexenones.