Changes in estimated glomerular filtration rate in chronic myeloid leukemia patients treated front line with available TKIs and correlation with cardiovascular events

医学 尼罗替尼 达沙替尼 内科学 伊马替尼 肾功能 髓系白血病 酪氨酸激酶抑制剂 队列 肿瘤科 甲磺酸伊马替尼 肾脏疾病 心脏病学 癌症
作者
Matteo Molica,Emilia Scalzulli,Gioia Colafigli,Danilo Alunni Fegatelli,Fulvio Massaro,Roberto Latagliata,Robin Foà,Massimo Breccia
出处
期刊:Annals of Hematology [Springer Science+Business Media]
卷期号:97 (10): 1803-1808 被引量:22
标识
DOI:10.1007/s00277-018-3375-9
摘要

We investigated the median estimated glomerular filtration rate (eGFR) changes in chronic myeloid leukemia (CML) patients treated front line with tyrosine kinase inhibitors (TKIs). A large cohort of 397 patients-320 treated front line with imatinib, 25 with dasatinib, and 53 with nilotinib-was retrospectively analyzed at a single institution. The eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration equation for all patients at baseline and then at 6 and 12 months, and at the last follow-up. Taking into account eGFR changes during the first year of treatment and excluding other possible cardiovascular risk factors, we considered also the percentage of cardiovascular events in patients with modifications of this single parameter. Imatinib induced a decrease in median eGFR (p = 0.01): 42 patients treated with imatinib had a cardiovascular event, related to modification of eGFR, in the absence of other cardiovascular risk factors. In patients treated with nilotinib, the median eGFR did not decline from baseline: only 1 patient experienced an ischemic event, but the eGFR remained unchanged. In patients treated with dasatinib, the mean eGFR did not change significantly: 3 patients experienced a cardiac ischemic event, but in all patients the eGFR remained unchanged over time, while advanced age and metabolic alterations contributed to the ischemic events. This long-term follow-up has documented that imatinib may induce changes in the eGFR, which may contribute to the onset of ischemic events. Further analyses on larger series of CML patients are required to conclusively define the potential renal toxicity of second generation TKIs and the consequent risk of developing ischemic events.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
雨晴完成签到,获得积分10
2秒前
jbq发布了新的文献求助10
2秒前
joshar完成签到,获得积分10
2秒前
3秒前
量子星尘发布了新的文献求助10
5秒前
blueblue完成签到,获得积分10
7秒前
落后秋烟完成签到,获得积分10
9秒前
大橙子发布了新的文献求助10
10秒前
LMY完成签到 ,获得积分10
10秒前
Betty完成签到 ,获得积分10
10秒前
NexusExplorer应助jbq采纳,获得10
11秒前
渔渔完成签到 ,获得积分10
11秒前
12秒前
Tangyartie完成签到 ,获得积分10
12秒前
skbkbe完成签到 ,获得积分10
13秒前
陈俊雷完成签到 ,获得积分0
14秒前
阿苗完成签到,获得积分10
15秒前
神勇的天问完成签到 ,获得积分10
16秒前
16秒前
advance完成签到,获得积分10
16秒前
李cc发布了新的文献求助10
17秒前
蒋念寒发布了新的文献求助10
18秒前
Sindy完成签到,获得积分10
18秒前
彭于晏应助HH采纳,获得30
20秒前
20秒前
朴实的小萱完成签到 ,获得积分10
21秒前
科研通AI5应助哭泣笑柳采纳,获得10
21秒前
21秒前
温暖的蚂蚁完成签到 ,获得积分10
24秒前
dhn123完成签到,获得积分10
24秒前
ccx完成签到,获得积分10
24秒前
25秒前
biofresh发布了新的文献求助30
25秒前
科研顺利完成签到,获得积分10
26秒前
Owen应助科研通管家采纳,获得10
27秒前
JamesPei应助科研通管家采纳,获得10
27秒前
NexusExplorer应助科研通管家采纳,获得30
28秒前
Nick应助科研通管家采纳,获得10
28秒前
28秒前
Ava应助科研通管家采纳,获得10
28秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022