Changes in estimated glomerular filtration rate in chronic myeloid leukemia patients treated front line with available TKIs and correlation with cardiovascular events

医学 尼罗替尼 达沙替尼 内科学 伊马替尼 肾功能 髓系白血病 酪氨酸激酶抑制剂 队列 肿瘤科 甲磺酸伊马替尼 肾脏疾病 心脏病学 癌症
作者
Matteo Molica,Emilia Scalzulli,Gioia Colafigli,Danilo Alunni Fegatelli,Fulvio Massaro,Roberto Latagliata,Robin Foà,Massimo Breccia
出处
期刊:Annals of Hematology [Springer Science+Business Media]
卷期号:97 (10): 1803-1808 被引量:22
标识
DOI:10.1007/s00277-018-3375-9
摘要

We investigated the median estimated glomerular filtration rate (eGFR) changes in chronic myeloid leukemia (CML) patients treated front line with tyrosine kinase inhibitors (TKIs). A large cohort of 397 patients-320 treated front line with imatinib, 25 with dasatinib, and 53 with nilotinib-was retrospectively analyzed at a single institution. The eGFR was calculated according to the Chronic Kidney Disease Epidemiology Collaboration equation for all patients at baseline and then at 6 and 12 months, and at the last follow-up. Taking into account eGFR changes during the first year of treatment and excluding other possible cardiovascular risk factors, we considered also the percentage of cardiovascular events in patients with modifications of this single parameter. Imatinib induced a decrease in median eGFR (p = 0.01): 42 patients treated with imatinib had a cardiovascular event, related to modification of eGFR, in the absence of other cardiovascular risk factors. In patients treated with nilotinib, the median eGFR did not decline from baseline: only 1 patient experienced an ischemic event, but the eGFR remained unchanged. In patients treated with dasatinib, the mean eGFR did not change significantly: 3 patients experienced a cardiac ischemic event, but in all patients the eGFR remained unchanged over time, while advanced age and metabolic alterations contributed to the ischemic events. This long-term follow-up has documented that imatinib may induce changes in the eGFR, which may contribute to the onset of ischemic events. Further analyses on larger series of CML patients are required to conclusively define the potential renal toxicity of second generation TKIs and the consequent risk of developing ischemic events.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
精则养神完成签到,获得积分10
刚刚
1秒前
1秒前
zz完成签到,获得积分10
1秒前
慕青应助WeiBao采纳,获得10
1秒前
1秒前
FashionBoy应助阔达靖琪采纳,获得10
2秒前
lu完成签到,获得积分20
3秒前
搜集达人应助eternal_dreams采纳,获得10
3秒前
4秒前
4秒前
sbw发布了新的文献求助10
5秒前
江江江11发布了新的文献求助10
5秒前
6秒前
sup发布了新的文献求助10
6秒前
Lucas应助bofu采纳,获得10
9秒前
zz发布了新的文献求助10
9秒前
11秒前
大黄柿子发布了新的文献求助10
11秒前
等待的友琴完成签到,获得积分20
11秒前
量子星尘发布了新的文献求助10
12秒前
wanci应助CC悟了采纳,获得10
12秒前
12秒前
cherlie应助羽生采纳,获得10
13秒前
Owen应助羽生采纳,获得10
13秒前
13秒前
YSY发布了新的文献求助30
13秒前
肖的花园完成签到 ,获得积分10
14秒前
14秒前
年轻半雪发布了新的文献求助10
15秒前
澡雪发布了新的文献求助10
15秒前
16秒前
完美世界应助科研通管家采纳,获得10
17秒前
脑洞疼应助科研通管家采纳,获得30
17秒前
领导范儿应助科研通管家采纳,获得10
17秒前
香蕉觅云应助科研通管家采纳,获得10
17秒前
情怀应助bofu采纳,获得10
17秒前
华仔应助科研通管家采纳,获得10
17秒前
慕青应助科研通管家采纳,获得10
17秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975722
求助须知:如何正确求助?哪些是违规求助? 3520056
关于积分的说明 11200719
捐赠科研通 3256455
什么是DOI,文献DOI怎么找? 1798271
邀请新用户注册赠送积分活动 877490
科研通“疑难数据库(出版商)”最低求助积分说明 806390