选择性
催化作用
溶剂
化学
微波辐射
产量(工程)
同种类的
吡那考
组合化学
有机化学
材料科学
物理
热力学
冶金
作者
Muriel Billamboz,Estelle Banaszak,Benoı̂t Rigo
标识
DOI:10.1002/slct.201802351
摘要
Abstract Here we report an efficient solvent‐free pinacolic‐pinacolone rearrangement using supported acids. Given a standard procedure (5 minutes microwave heating at 180 °C), changing the acid catalyst allow to reverse the selectivity of the reaction. The optimized conditions represent an efficient means by which pinacol‐pinacolone rearrangement can be carried out while avoiding the use of strong homogeneous Brönsted acids and extended reaction times. This neat reaction gave the products in high yield, purity and ease of recovery. Moreover, the catalyst can be reused on 10 runs without any loss of activity nor selectivity. As a consequence, that protocol can be referred as a green and efficient process for pinacol‐pinacolone rearrangement.
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