Curvature-Mediated Pair Interactions of Soft Nanoparticles Adhered to a Cell Membrane

曲率 粘附 纳米颗粒 纳米技术 膜曲率 生物物理学 材料科学 胶粘剂 化学 化学物理 小泡 复合材料 生物化学 生物 数学 几何学 图层(电子)
作者
Tongwei Chen,Yunhan Zhang,Xuejin Li,Chengxu Li,Teng Lu,Shiyan Xiao,Haojun Liang
出处
期刊:Journal of Chemical Theory and Computation [American Chemical Society]
卷期号:17 (12): 7850-7861 被引量:4
标识
DOI:10.1021/acs.jctc.1c00897
摘要

The curvature-mediated interactions by cell membranes are crucial in many biological processes. We systematically studied the curvature-mediated wrapping of soft nanoparticles (NPs) by a tensionless membrane and the underlying pair interactions between NPs in determining it. We found that there are three types of wrapping pathways, namely, independence, cooperation, and tubulation. The particle size, adhesion strength, and softness are found to be strongly related with the wrapping mechanism. Reducing the adhesion strength transforms the wrapping pathway from cooperation to independence, while enhancing the NP softness requires a stronger adhesion to achieve the cooperative wrapping. This transformation of the wrapping pathway is controlled by the curvature-mediated interactions between NPs. For either soft or rigid NPs, the pair interactions are repulsive at short-ranged distances between NPs, while at long-ranged distances, a larger adhesion between NPs and a membrane is needed to generate attraction between NPs. Moreover, an enhancement of NP softness weakens the repulsion between NPs. These distinct behaviors of soft NPs are ascribed to the gentler deformation of the membrane at the face-to-face region between NPs due to the flattening and spreading of soft NPs along the membrane, requiring a reduced energy cost for soft NPs to approach each other. Our results provide a mechanistic understanding in detail about the membrane-mediated interactions between NPs and their interactions with cell membranes, which is helpful to understand the curvature-mediated assemblies of adhesive proteins or NPs on membranes, and offer novel possibilities for designing an effective NP-based vehicle for controlled drug delivery.
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