神经病理性疼痛
小RNA
三叉神经节
组蛋白
基因表达调控
神经科学
表观遗传学
慢性疼痛
痛觉超敏
乙二醇
化学
细胞生物学
医学
生物信息学
生物
作者
Renfei Qi,Junping Cao,Yufang Sun,Yanping Li,Zitong Huang,Dongsheng Jiang,Xing-Hong Jiang,Terrance P. Snutch,Yuan Zhang,Jin Tao
标识
DOI:10.1073/pnas.2117209119
摘要
Significance In this study, we identify microRNA-32-5p (miR-32-5p) as a key functional noncoding RNA in trigeminal-mediated neuropathic pain. We report that injury-induced histone methylation attenuates the binding of glucocorticoid receptor to the promoter region of the miR-32-5p gene and decreases the expression of miR-32-5p, in turn promoting the development of neuropathic pain through regulation of Cav3.2 channels. miRNA-mediated gene regulation has been proposed as a therapeutic approach in neuropathic pain. Our findings identify miR-32-5p replenishment as a therapeutic strategy for treating chronic neuropathic pain.
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