上睑下垂
内部收益率3
炎症体
内质网
未折叠蛋白反应
刺
半胱氨酸蛋白酶1
医学
免疫学
干扰素基因刺激剂
干扰素调节因子
细胞生物学
癌症研究
炎症
生物
免疫系统
先天免疫系统
航空航天工程
工程类
作者
Tuo Han,Ting Zhang,Yajie Fan,Congxia Wang,Yan Zhang
出处
期刊:Exploratory research and hypothesis in medicine
[Xia & He Publishing]
日期:2022-02-15
卷期号:7 (2): 88-94
被引量:1
标识
DOI:10.14218/erhm.2021.00052
摘要
Myocardial ischemia/reperfusion (I/R) exacerbates ischemic cell death, in which endoplasmic reticulum (ER) stress and pyroptosis have major implications. Previous evidence showed that the stimulator of interferon genes/ interferon regulatory factor (STING/IRF3) pathway regulates numerous immune and inflammatory responses and is implicated in a range of autoimmune diseases, pathogenic infections, cancer, and cardiovascular diseases. Our most recent study linked STING activation to ER stress and the unfolded protein response (UPR). In addition, STING has a potential role in activating the NOD-like receptor protein 3 (NLRP3)/caspase-1 inflammasome cascade and inducing cell pyroptosis. Therefore, the STING/IRF3 pathway could be a bridge between the upstream ER and oxidative stress and downstream NLRP3/Caspase-1 pathway and pyroptosis and the expression and release of the inflammatory cytokines interleukin-1 (IL-1β) and interleukin-18 (IL-18) triggers, and therefore, myocardial I/R injury. The targeting of STING/IRF3 is of increasing interest in therapeutic agents to reduce I/R injury.
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